Effect of glurenorm on immunohistochemical changes in pancreatic beta cells of rats in experimental diabetes.
نویسندگان
چکیده
Immunohistochemical localization of islets of Langerhans of streptozotocin (65 mg/kg, ip) induced diabetic + glurenorm (10 mg/kg, po) treated female albino rats revealed increase in number of beta cells and insulin immunoreactivity of beta cells. The results suggest that glurenorm can cause the stimulation of beta cells of endocrine pancreas in diabetic rats.
منابع مشابه
HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF PANCREATIC ISLET BETA CELLS OF DIABETIC RATS TREATED WITH ORAL VANADYL SULPHATE
Vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. The aim of the present study was to clarify histological and immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl sulphate (VS)-treated streptozotocin (STZ) induced diabetic rats. Male Wi star rats were made diabetic by injecting a single intravenous dose of STZ (...
متن کاملTHE EFFECT OF INTENSE PERIODIC EXERCISE AND CONSUMPTION OF BLACK GRAPE SEED EXTRACT ON BAX AND BCL-2 GENE EXPRESSION IN PANCREATIC TISSUE OF MALE RATS WITH TYPE 2 DIABETES
Background: Although some studies have studied the mechanism of action of beta cells in animal models and more or less in human populations, but so far the role of exercise therapy or exercise exercise HIIT with black grape supplementation on the expression of genes involved in pancreatic beta cells This study investigates the effect of black grape supplementation combined with intense intermit...
متن کاملTHE EFFECT OF 8 WEEKS OF HIGH INTENSITY INTERVAL AND ENDURANCE TRAINING ON LIPASIN GENE EXPRESSION IN RATS WITH TYPE 2 DIABETES
Background: The prevalence of type 2 diabetes is rapidly increasing in the world. As a result of this disease, long-term insulin resistance develops, as a result of which pancreatic beta cells are destroyed and disappear, as a result insulin is not released. Recently, a protein called lipasin, which is responsible for signaling the liver to beta cells, has been discovered, and previous reports ...
متن کاملSilymarin: a novel natural agent to restore defective pancreatic beta cells in Streptozotocin (STZ)-induced diabetic rats
This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...
متن کاملSilymarin: a novel natural agent to restore defective pancreatic beta cells in Streptozotocin (STZ)-induced diabetic rats
This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 43 3 شماره
صفحات -
تاریخ انتشار 2005